教学工作

本科生《实验药理学》

研究生《药理学研究导论》《实验技术与仪器分析》

研究领域

         King's Lab provides the following collaborations and contract services:

             1) Evaluation of pharmacodynamics and animal disease models;

             2) Assesment of pharmacokinetics and drug matablism;

             3) Performance of SpinalScreen Assay®. 

项目

1. 提供药效学和动物疾病模型.

2. 蛋白、肽类药物和小分子药物动力学.

3. 脊髓药物快速筛选.

专利

1. Lei Fu, Yuxu Hong, Xiaobo Li, Yongxiang Wang, Hongwei Wang & Zhongyun Liu;Preparation method of nano cordyceps militaris powder for improving bioavailability of cordycepin, polysaccharide and adenosine;专利号：CN 103229994 A.

2. Wang Y.-X., Fu L., Xie D.-S. & Lu J.;Novel DAAO inhibitors and their preparation and usage;专利号：201310362881.7.

3. Wang Y.-X., Li X.-Y. & Chen X.-L.;Inhibiton and usage of siRNA on DAAO expression;专利号：CN 102604950 A.

4. Zhong J.-P., Wang Y.-X., Chang J., Xu Y.-H. & Ma A.-N.;A pH buffer composition for bioglass against peptic ulcers;专利号：CN 103006700 A.

5. Wang, Y.-X., Gong N. & Huang J.-L.;Inhibitors of DAAO are used for the prevention and/or revision of opioids tolerance;专利号：CN 102727896 A; WO 2012/139529.

6. Wang Y.-X. & Gong N.;Agonists of GLP-1 receptors are used for the treatment of pain.;专利号：CN 102614514 A; WO/2012/100748.

7. Xu M., Wang Y.-X., Zhang Y.-H., Luo X.-S., Gong N. Zhang L-J. & Zhou X.-J;New Exendin analogs and their PEGylated derivatives.;专利号：CN 102421796 A; US20120196795 A1；EP2423223 A1；WO2010121559 A1.

8. Zhou X.-J., Huang W.-L. Wang Y.-X. & Pan W.-B.;A new anti-cancer drug;专利号：CN 1820785 A.

论文

1. Contributions of spinal D-amino acid oxidase to chronic morphine-induced hyperalgesia.Ma S., Li X.-Y., Gong N. & Wang Y.-X.J. Pharm. Biomed. Anal. DOI.

2. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain.Li T.-F., Fan H. & Wang Y.-X.PLoS ONE.

3. Gelsemium analgesia and the spinal glycine receptor/allopregnanolone pathway.Zhang J.-Y. & Wang Y.-X..Fitoterapia.

4. The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia.Fan H., Gong N., Li T.-F., Ma A.-N., Wu X.-Y., Wang M.-W. & Wang Y.-X..Br. J. Pharmacol.

5. Targeted gene suppression by inducing de novo DNA methylation in the gene promoter.Ma A.-N., Wang H., Guo R., Wang Y.-X., Li W., Cui J.-W., Wang G.-J., Hoffman A.R. & Hu J.-F.Epigen. Chrom.

6. Lamiophlomis rotata, an orally available Tibetan herbal painkiller, specifically reduces pain hypersensitivity through the activation of the spinal glucagon-like peptide-1 receptors.Zhu B., Gong N., Fan H., Peng C.-S., Ding X.-J., Jiang Y. & Wang Y.-X..Anesthesiology.

7. Quinoxaline-2,3-diones: Potential D-amino acid oxidase (DAAO) inhibitors.Xie D.-S., Wang Y.-C., Xie J., Lu J., Cui J., Zhang M., Fu L. & Wang Y.-X..Med. Chem. Res..

8. Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors.Gong N., Fan H., Ma A.-N., Xiao Q. & Wang Y.-X..Neuropharmacology.