研究领域

1.生物技术药物：生物催化是合成复杂结构药物或前体的重要手段。应用浊点系统技术解除生物催化（微生物转化与发酵）过程中存在的底物生物利用度低、底物/产物抑制、产物进一步降解等瓶颈问题。

2. 微生物次级代谢：微生物次级代谢受到多种环境因素的调控。应用浊点系统萃取发酵技术改变营养物质的吸收和次级代谢产物的分泌，进而调控微生物次级代谢的途径及效率。

论文

1. Transferring of red Monascus pigments from nonionic surfactant to hydrophobic ionic liquid by novel microemulsion extraction.Lingjie Shen, Xuehong Zhang, Mingzhu Liu, Zhilong Wang.Separation and purification technology.

2. Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution.Xu Xiong, Xuehong Zhang, Zhenqiang Wu, Zhilong Wang.Applied microbiology and biotechnology.

3. Sunghoon Park. Production of citrinin-free Monascus pigments by submerged culture at low pH..Biyu Kang, Xuehong Zhang, Zhenqiang Wu, Zhilong Wang.Enzyme and microbial technology.

4. Effect of pH and nonionic surfactant on profile of intracellular and extracellular Monascus pigments.Biyu Kang, Xuehong Zhang, Zhenqiang Wu, Hanshi Qi, Zhilong Wang.Process biochemistry.

5. Export of intracellular Monascus pigments by two-stage microbial fermentation in nonionic surfactant micelle aqueous solution..Zhiqiang Hu, Xuehong Zhang, Zhenqiang Wu, Hanshi Qi, Zhilong Wang.Journal of biotechnology.

6. Perstraction of intracellular pigments by submerged cultivation of Monascus in nonionic surfactant micelle aqueous solution.Zhiqiang Hu, Xuehong Zhang, Zhenqiang Wu, Hanshi Qi, Zhilong Wang.Applied microbiology and biotechnology.